If the “Signatures” button fails to open the dialogue box for changing your signature, you can take the following steps:
- Locate: [HKEY_LOCAL_MACHINE\SOFTWARE\Classes\Wow6432Node\CLSID\{0006F03A-0000-0000-C000-000000000046}\LocalServer32]
- Direct it to outlook.exe
This file can be renamed .reg and imported to fix this issue on Office 365: Office365